Irish scientists at the Advanced Materials and BioEngineering Research Centre (AMBER) have developed HydroxyColl, a patented bone restoration technology that has saved a racing horse’s life by reconstructing its jawbone. The new technology called HydroxyColl was presented at AMBER’s first Industry Day anniversary held at the Trinity College in Dublin.

The research team was led by Professor Fergal O’Brien, deputy director in AMBER and research director at the Royal College of Surgeons in Ireland (RCSI). The technology uses bone components such as collagen and hydroxyapatite to form a 3D porous scaffold where bone cells and blood vessels attach so tissue regeneration could begin.

The first clinical use of the HydroxyColl was on a 2 year old thoroughbred filly that had a large swelling in her jaw caused by a complex aneurysmal cyst. As a result of the cyst, the bone in the filly’s jaw was at risk of fracture and she was unable to chew adequately. The outcome is generally poor for aneurysmal cysts and euthanasia of the animal often necessary.

The procedure was carried out by Dr. Florent David at University College Dublin’s Veterinary Hospital who removed the cyst and implanted sheets of the scaffold. The procedure has enabled repair of the bone tissue followed by restoration of normal bone shape and function. Since surgery, the horse (Annagh Haven) has returned to racing and has won or been placed in 6 of her races to date.

HydroxyColl will be brought to market by RCSI spin out, now an Enterprise Ireland supported company, SurgaColl Technologies. This medical company engages in supplying unique tissue restoration products for the surgical treatment of certain body parts. The new AMBER technology is seeking regulatory approval for clinical trials on humans. Patients enduring major bone damage will benefit from successful implantations.

Damien English, Minister for Skills Research and Innovation said: “I congratulate Professor O’Brien, his team and collaborators at AMBER for this breakthrough solution that could have real application in the veterinary sector and which could also ultimately improve the lives of thousands of people.”

At the event, Prof Stefano Sanvito, acting director of AMBER, also stated that the creation of the new scaffold technology demonstrates AMBER’s track record of pushing the boundaries of science to explore real solutions for people. “We will continue to carry out excellent research that has clear societal impact,” he added.